Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review

Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review

The FDA recommends to start elderly patients on the 5mg dose and slowly titrate to a therapeutic dose from there. However, other drugs may work better for neck and back pain than muscle relaxants. The first line of treatment for can you buy flexeril over the counter muscle spasms and muscle pain is over-the-counter medications like Tylenol (acetaminophen) and nonsteroidal anti-inflammatory drugs (ibuprofen, naproxen). Muscle relaxants do carry side effects just like any other medications.

Muscle relaxant use common among patients on hemodialysis and … – Healio

Muscle relaxant use common among patients on hemodialysis and ….

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Both tizanidine (Zanaflex) and cyclobenzaprine (Flexeril) are effective muscle relaxants commonly used for the treatment of muscle spasms. They were approved by the FDA only a few years apart, with Flexeril having been available slightly longer than Zanaflex. Zanaflex is a relatively new medicine that has been licensed by the FDA to treat muscle spasticity caused by multiple sclerosis and spinal cord injury. Flexeril is an older medication that has been examined extensively for musculoskeletal pain and spasms.

During spasticity, “the muscles remain contracted and resist being stretched, thus affecting movement, speech and gait,” the American Association of Neurological Surgeons explains. Enter search terms to find related veterinary topics, multimedia and more. My rheum also added Gabapentin, which is something I’ve been wanting to try, and seems fairly common in treatment regimes for fibro.


Any drug information published on regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

With regards to safety profiles, it is worth noting that while both medications have potential side effects including dizziness and sedation, some studies have suggested that tizanidine may be better tolerated overall. It’s also important to note that cyclobenzaprine is generally considered a first-line treatment option due its long history of use and extensive research supporting its safety and efficacy. Tizanidine tends not to be prescribed until other options like NSAIDs or physical therapy have failed or aren’t suitable. Over 100 trials comparing muscle relaxants such as Lioresal (baclofen), Soma (carisoprodol), Robaxin (methocarbamol), Skelaxin (metaxalone), and Valium were included in the meta-analysis (diazepam).

  • Consulting with a healthcare professional is crucial to determine the most appropriate medication for each individual’s needs.
  • It starts with once daily doses that are to be incrementally increased to an eventual four times daily dose.
  • The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
  • Tizanidine and Flexeril are both muscle relaxers that can be used with a physical therapy program.

There is a large degree of variability in recent studies evaluating the efficacy of oral baclofen in patients with cerebral palsy. Current evidence points to an improvement in muscle tone and strength with oral baclofen use, although this effect may be short-term and prolonged use may cause increased weakness in patients. In addition, other muscle relaxants such as tolperisone and tizanidine, show similar efficacy to oral baclofen, with reduced side effects in recent trials.

Popularity of Zanaflex and Flexeril

In contrast to Zanaflex, Methocarbamol can be administered orally and parentally and is one of the cheapest muscle relaxants available. Based on research published in the Canadian Journal of Neurosciences, both medications have similar efficacy. However, the after-effects are slightly different and can influence drug choice. These medications can slow down the breakdown of tizanidine and lead to increased sedation, drowsiness and slowed reflexes. Always inform your doctor if you are taking any other medicine and of any medical conditions, like liver or kidney disease, before getting prescribed either medication is essential.

You can also take advantage of a Flexeril coupon to get a reduced price of around $7 at a participating pharmacy. Drugs like Zanaflex and Flexeril are often recommended along with physical therapy to relieve pain. Consult a healthcare provider to determine the best treatment option for you. Zanaflex (What is Zanaflex?) is the brand name for tizanidine and acts as an alpha-2 adrenergic agonist. It was initially approved in 1996 for the treatment of muscle spasticity. Although its exact mechanism of action is unknown, it is believed to manage muscle spasticity through the inhibition of motor nerve signals.

The most common side effects of Zanaflex include dry mouth, drowsiness, dizziness, muscle weakness or fatigue, and constipation. Other reported side effects include urinary tract infections (UTIs) and involuntary movements (dyskinesia). Spasticity refers to spasms or tightness that occur when the muscles remain contracted and are resisting being stretched, affecting movement, gait, and speech. Tizanidine and cyclobenzaprine use in high doses can cause liver damage.

Reviewing your symptoms, current medication list, and medical history with your healthcare provider is the best way to decide which muscle relaxer will work best. Drinking alcohol while taking Zanaflex or Flexeril can enhance the sedative effects of these drugs. It is not generally recommended to drink alcohol with muscle relaxants.






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